Internet delivered cognitive behavior therapy for antenatal depression: A randomised controlled trial.

Source: Forsell, E., et al. 2017 - Pubmed ID: 28628768

Setting: Sweden,

Study design:



Follow up: 10 weeks

Patient group:

Sample size:

Total: 42 (39)

IG: 22 (21)

CG: 20 (18)


Inclusion criteria:

  • Pregnant 10>28 weeks
  • Meet diagnostic criteria for major depression.
Type of technology:


  • Education
  • Information
  • Messaging

Intervention: Guided self-help treatment where reading material (about 75,000 words), assessments, homework and work-sheets were delivered via a secure online platform. Patients also had a therapist providing regular feedback, encouragements and support in written messages 


Duration: 10 weeks
Add on: +


Control group: Usual care

Clinical effect/ Patient safety:

Clinical effect:

  • MADRS-S (depression) ↓ (improved
  • EPDS →

Patient safety:

  • Two patients reported one minor adverse event, which was that they felt stressed about not keeping up with the treatment program.
Patient experiences/ Staff experiences:

Patient experiences:

  • Good satisfaction
  • Logged in 34.1 times during 10 weeks treatment.

Staff experiences:

Costs and organization:

Staff resources

  • Development of online platform

Staff resources

  • Messaging patients


Organization:  NA


Health care utilization: NA

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“↑”: Statistically significant increase

“↓”: Statistically significant decrease

“→”: Statistically insignificant (no difference)